Free POST Trial Brief - District Court of Delaware - Delaware


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Date: January 30, 2008
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State: Delaware
Category: District Court of Delaware
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Case 1:06-cv-00033-SLR

Document 179-2

Filed 01/30/2008

Page 1 of 1

APPENDIX A

Timeline of Takeda's Development of Lansoprazole Using Me-Too Approach
AG-1511 synthesized 7/83 Random Screening and NCE Approach by Takeda 1/82 AG-1414 (omeprazole) synthesized 5/83 AG-1598 synthesized 10/83 AG-1749 (lansoprazole) synthesized 5/84

1982

1983

1984

Substituents Used By Takeda During The Development of Lansoprazole Methyls and Fluorinated Methyls Ethyls Alkoxies, Fluoroalkoxies, and Alkoxy-Linked Substituents -CH3, -CH2CH3; -CF3 -CH2CH3 ­OCH3; ­OCH2; ­OCH2CH3; ­O(CH2)2CH3; ­O(CH2)3CH3; ­ O(CH2)5CH3; ­O(CH2)7CH3; ­OC6H5; ­OCH2C6H5; ­ OCH(CH3)2; ­OCH2C(CH3)3; ­OCH2CH(CH3)2; ­OCHCH; ­ OCH2CCH; ­OCH2CHCH2; ­OCH2CF3; ­OCH2CF2CF3

Halogen

-F