Free Proposed Pretrial Order - District Court of Delaware - Delaware

Case 1:04-cv-00179-SLR

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CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 REDDY'S TRIAL EXHIBIT LIST Trial Ex. No. DTX 1 Bates No. BL005-001285 - 1301 Description Protokoll der 2. Projektbesprechung Chinolone au 25.11.1987 (D1) (and certified translation) Protokoll der 3. Projektbesprechung Chinolone au 26.1.1988 (D2) (and certified translation) "Protokoll der 28. Projektbesprechung Chinolone 25.9.1990" (D3) (and certified translation, BL005-101012 ­101013, BL005-101017 - 101022) Egawa et al., "Pyridonecarboyxlic Acids as Antibacterial Agents," J. Med. Chem. 1984, 27, 1543-1548 (D4) Letter to Dr. Petersen with attachments (D5) (and certified translation, BL005-052214) Doc. Date 11/25/87 Objections1 Relevance

DTX2

BL005-001268 ­ 001284

1/28/88

Relevance

DTX3

BL002-101012 ­ 101065

9/28/90

Relevance

DTX4

BL005-051682 ­ 051687

1984

Relevance, Hearsay

DTX5

BL005-052214 - 052218

11/24/87

Relevance, Hearsay as to attachments

As used in the foregoing objections, "Relevance" refers to Federal Rules of Evidence 401, 402, and 403; "Hearsay" refers to Federal Rules of Evidence 801, 802, and 805; "Authenticity" refers to Federal Rule of Evidence 901; "Lack of Foundation" refers to Federal Rules of Evidence 602 and 901; "Multiple Documents" refers to Federal Rules of Evidence 401, 402, 403, 1001, 1002, and 1003; "Incomplete" refers to Federal Rules of Evidence 106, 401, 402, and 403; and "Inadmissible Demonstrative" refers to Federal Rules of Evidence 401, 402, 403, and 901. By setting forth these objections to the documents on Reddy's Trial Exhibit list, Bayer does not concede that the descriptions of the documents on Reddy's list are necessarily accurate. Bayer reserves its right to object further to documents on or added to this list on any basis that depends upon how a document is introduced, for what purpose a document is introduced, and what portion of a document is introduced. Page 1 of 39
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Trial Ex. No. DTX6

Bates No. BL018-120109 ­ 120167

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Chinoloncarbonsauren mit 7(Hydroxypyrrolidinyl)-, 7(Hydroxy-piperidinyl)-bzw. 7(Hydroxyazetidinyl)-Resten (Chinoloncarbonsauren, Teil 11) (D6) INTENTIONALLY LEFT BLANK Laboratory notebook pages, PEW 6893, N5088 (D8) Laboratory notebook pages, PEW 6902 (D9) Laboratory notebook pages, PEW 6957 (D10) Bayer Organization Plan (D11) Status Report: AK Research "Quinolones" 1992 (D12) Statusbericht 1985 ­ AKF "Antibakterielle Therapie" (D13) (and certified translation) Statusbericht 1986 ­ AKF "Antibakterielle Therapie" (D14) (and certified translation) Statusbericht 1987 ­ AKF "Antibakterielle Therapie" (D15) (and certified translation) "Statusbericht 1988 ­ AKF "Antibakterielle Therapie" (D16) (and certified translation) "Statusbericht 1989" (D17) 2/15/88

Objections1 Relevance

DTX7 DTX8 DTX9 DTX10 DTX11 DTX12 DTX13

BL008-012394 ­ 012416 BL008-012351 ­ 012365 BL008-012124 ­ 012159 BL010-005257 ­ 005493 BL002-096056 ­ 096093 BL002-100310 ­ 100343

7/2/90 2/26/90 10/4/90 1/1/88 1/8/93 1/21/86

Relevance Relevance Relevance Relevance Relevance Relevance

DTX14

BL002-100266 ­ 100309

1/26/87

Relevance

DTX15

BL002-100216 ­ 100265

1/26/88

Relevance

DTX16

BL002-100063 ­ 100132 BL002-100133 ­ 100169; BL005-044708 ­ 044709

1/16/89

Relevance

DTX17

1/14/90

Relevance

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Trial Ex. No. DTX17A

Bates No. BL0054470844748 BL002-096340- 096380 BL002-096239 ­ 096283 BL002-096010 ­ 096054 BC004-001072 ­ 001191

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date "Statusbericht 1989" 1/14/90

Objections1 Relevance

DTX18 DTX19 DTX20 DTX21

DTX22

BL009-036178

Status Report: AK Research "Antibacterial Therapy" 1990 (D18) Status Report: AK Research "Antibacterial Therapy" 1991 (D19) Status Report: AK Research "Quinolones" 1993 (D20) Dr. med. R. Kubin Confidential Investigator's Brochure ­ First Edition (August 1992) ­ Bay y 3118 Fluoroquinolone Antibiotic (D21) Poster and Close-up (D22)

1/16/91 1/9/1992 1/5/94 8/92

Relevance Relevance Relevance Relevance

DTX22A

BL009-036178

Poster and Close-up (D22A)

DTX23 DTX24

DRLMOX 040973 ­ 040982 BL002-101209

US Patent No. 4,666,920 (D23) Letter from N. Robillard (Miles) to B. Painter enclosing proposal for strategies to overcome quinolone resistance to be presented to Dr. Zeiler (with handwritten note to Hans from Barbara) (D24) Thurberg, at al., "In Vitro Activity of Bay Y 3118, a New Quinolone" (D25)

5/19/87 3/28/90 (3/22/90)

Relevance, Multiple Documents Relevance, Multiple Documents Relevance Relevance, Hearsay

DTX25

SH_000001-005240 ­ 005242

Relevance, Hearsay

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Trial Ex. No. DTX26 DTX27 DTX28 DTX29 DTX30 DTX31 DTX32 DTX33

Bates No. DRLMOX 030539 ­ 030564 DRLMOX 030468 ­ 030521 DRLMOX 008890 ­ 009078

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date US Patent No. 5,173,484 (D26) US Patent No. 4,990,517 (D27) Certified copy of EP 0 241 206 (D28) 30(b)(6)Notice of deposition of Bayer (D29) Report page, Dr. Peterson (D30) Report page, Dr. Peterson (D31) Report page, Dr. Peterson (D32) Fournel (Miles) Fax to Bremm, 11/11/92 re: data on mycobacteria and Y3118 (D33) Minutes of Emergency Team Meeting: Bay Y 3118, 3/93 (D34) 12/22/92 2/5/91 10/14/87 4/20/05 7/26/90 10/4/90 5/18/90 11/11/92

Objections1 Relevance

Relevance, Hearsay Relevance, Hearsay Relevance Relevance Relevance Relevance, Hearsay

BL002-015256 BL002-015187 BL005-017418 BL002-127268 ­ 127269

DTX34

BL005-047236 ­ 047247

3/17/93

DTX35 DTX36 DTX37

BL002-097136 ­ 097142 BL002-097006 ­ 097043 BL002-134176 -134177

DTX38

BL002-134026 ­ 134081

DTX39

BL001-014381 -14382

Bremm paper, "DU-6859: A New Generation of Quinilone?" (D35) Status Report AK Research "Quinolones" 1994 (D36) Minutes of Meeting, PC 10/94, November 3, 1994 re: Cipro, new quinolones, etc. (D37) BAY 11-6371 (tosylate) and BAY 12-8039 (hydrochloride): Results of the microbiological tests (D38) Combined Declaration and Power of Attorney (US Serial No. 08/026,906) (D39) Page 4 of 39

7/13/94 1/16/95 11/3/94

Relevance, Authenticity as to handwriting on page 2 Relevance Relevance Relevance

3/10/95

Relevance

4/20/93

Relevance

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Trial Ex. No. DTX40 DTX41 DTX42 DTX43 DTX44

Bates No. BL001-014002 - 014135 DRLMOX 038825 ­ 038829

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Patent Application for LeA 26 108US/03 CIP (D40) Declaration of Klaus-Deiter Bremm (US Serial No. 08/026,906) (D41) INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK Declaration of Klaus-Dieter Bremm (D44)

Objections1 Relevance

12/2/94

Relevance

DRLMOX 038830 ­ 038846

7/20/95

DTX45 DTX46 DTX47 DTX48 DTX49

DRLMOX 008693 ­ 008697 DRLMOX 041391 ­ 041521 DRLMOX 041016 ­ 041206 DRLMOX 041210 ­ 041390 DRLMOX 008179 ­ 008556 DRLMOX 008557 ­ 008889

DTX49A

DTX50 DTX51 DTX52 DRLMOX 033497 ­ 033549

Declaration of Klaus-Dieter Bremm (D45) German patent application (P 38 24 072.6) (D46) German patent application (07 375434) re: Le A 26 108 (D47) German patent application (07 375434) re: P 39 06 365.8) (D48) Certified file history, US Patent Application No. 07/298,459 (Part 1 of 2) (D49) Certified file history, US Patent Application No. 07/298,459 (Part 2 of 2) (D49A) Bayer v. DRL, Subpoena to Kurt Briscoe (D50) Bayer v. DRL, Subpoena to Norris, McLaughlin and Marcus, P.A. (D51) Certified Patent, U.S. Patent No. 5,607,942 (D52) Page 5 of 39

8/16/90 5/10/89 6/30/89 4/13/89 1/18/89

Relevance, Incomplete, Hearsay as to attachment Relevance Relevance, Hearsay as to cover page Relevance Relevance, Hearsay as to cover page Relevance, Hearsay

1/18/89

Relevance, Hearsay

9/13/04 9/13/04 3/4/97

Relevance, Hearsay Relevance, Hearsay

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Trial Ex. No. DTX53 DTX54

Bates No. DRLMOX 007484 ­ 7485 DRLMOX 007487 ­ 007488 DRLMOX 038815 ­ 038817 DRLMOX 038852 ­ 038858

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Office Action: Issue Fee Transmittal (US Serial No. 07/375,434) (D53) Office Action: Information Disclosure Statement (US Serial No. 07/375,434) (D54) Office Action: Preliminary Amendment (US Serial No. 08/406,448) (D55) Information Disclosure Statement (US Serial No. 08/406,448) (D56) 8/27/90 11/16/90

Objections1 Relevance Relevance, Incomplete Relevance, Incomplete Relevance, Incomplete, Multiple Documents Relevance, Incomplete Relevance Relevance, Hearsay

DTX55

3/20/95

DTX56

2/29/96

DTX57 DTX58 DTX59

DRLMOX 038860 ­ 038863 DRLMOX 038819 ­ 038824 DRLMOX 038869 ­ 038892

DTX60

SH_000001-005104 ­ 005114 SH_000001-005115 ­ 005127 DRLMOX 038900 ­ 038909

DTX61

DTX62

Third Preliminary Amendment (US Serial No. 08/406,448) (D57) Preliminary Amendment (US Serial No. 08/406,448) (D58) Briscoe fax to Datlow (Patent Commissioner) attaching missing attachments to May 19, 1995 amendment (US Serial No. 08/406,448) (D59) Kraatz decision, USPTO Board of Patent Appeals and Interferences, Appeal No. 93-4186 (D60) Kraatz decision, USPTO Board of Patent Appeals and Interferences, Appeal No. 89-3761 (D61) File History Section US Serial No. 08/406,448) Amendment Under 37 CFR 1.111 (D62)

9/21/95 5/19/95 11/1/95

8/29/94

Relevance, Hearsay

2/13/91

Relevance, Hearsay

6/6/96

Relevance

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Trial Ex. No. DTX63

Bates No. SH_000001-000001 ­ 000005 SH_000001-000352 ­ 000353 SH_000001-001221 ­ 001222 SH_000001-008737 ­ 008925

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Cover sheet for patent file, attaching Request for Abstract of Title (US Serial No. 07/375,434) (D63) Request for Certification Under 37 CFR 1.322 (US Serial No. 375,434) (D64) Information Disclosure Statement (US Serial No. 580,906) (D65) European Patent Application, EP 0 241206 (D66) 6/28/99

Objections1 Relevance, Multiple Documents Relevance, Incomplete Relevance, Incomplete Relevance, Hearsay, Lack of Foundation, Multiple Documents Relevance, Hearsay Relevance Relevance, Incomplete Relevance, Incomplete Relevance, Incomplete Relevance, Incomplete Relevance

DTX64

2/16/95

DTX65 DTX66

2/14/91 3/31/87

DTX67 DTX68 DTX69

SH_000001-006980 007166 SH_000001-004571 SH_000001-004600

DTX70 DTX71 DTX72 DTX73

SH_000001-005134 ­ 005137 SH_000001-005176 ­ 005187 SH_000001-005153 ­ SH 000001 - 005163 SH_000001-005149 ­ 005150

European Patent Application EP 0 241206 A2 (D67) Cover Sheet for Patent File (US Serial No. 026,906) (D68) Briscoe letter to Pross (Patent Providers), requesting documents be filed with the Patent Office (D69) Second Amendment Under Rule 116 (US Serial No. 08/026,906) (D70) Amendment Under Rule 111 (US Serial No. 08/026,906) (D71) Amendment Under Rule 116 (US Serial No. 08/026,906) (D72) Notice of Appeal from the Primary Examiner to the Board of Patent Appeals and Interferences (US Serial No. 08/026,906) (D73) Page 7 of 39

3/31/87 3/5/93 11/8/94

12/15/94 2/16/94 11/8/94 11/10/94

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Trial Ex. No. DTX74 DTX75

Bates No. SH_000001-000067 ­ 000068 BL005-012468 ­ 012500

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Combined Declaration and Power of Attorney (D74) "Uber 1-Cyclopropyl-8-methoxychinoloncarbonsauren" (D75) (and certified translation) "Protokoll der 12.Projektbesprechung Chinolone au 22.12.1988" (D76) (and certified translation) "Projektbesprechung Antiinfektiva 11.Mai.1989", BL005-001315 ­ 1317, BL005-001347 ­ 1352, BL005-001354 ­ 1360) (D77) and certified translation Laboratory Notebook, Dr. Petersen, PEW 6731-6875 (D78) Laboratory Notebook, Dr. Petersen, PEW 6876-7000 (D79) U. Petersen, "Die Evolution der Chinolone: Von der Nalidixinsaure zu den Chinolonen der dritten Generation," Pharmazie in unserer Zeit, 10.jahrgang 2001, Nr. 5 (D80) (and certified translation, DRLMOX 030957 ­ 30964) Petersen Notebook, "Vortrags Folien" (D81) 6/22/89 6/2/93

Objections1 Relevance, Incomplete Relevance

DTX76

BL005-001123 ­ 001140

12/23/88

Relevance

DTX77

BL005-001315 ­ 001360

5/11/89

Relevance

DTX78 DTX79 DTX80

BL008-011000 ­ 011521 BL008-012000 ­ 012469 DRLMOX 030951 ­ 030956 (and certified translation, DRLMOX 030957 ­ 30964)

5/16/90 1/14/91 1/30/01

Relevance Relevance Relevance

DTX81

BL005-021000 ­ 021186

Relevance

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Trial Ex. No. DTX82

Bates No. BL005 - 023000 BL005 ­ 023386 BL005 ­ 023398 ­ 023453

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Pages from Petersen Notebook, "S. Sendung" 85-86 (D82)

Objections1 Relevance, Multiple Documents, Incomplete, Hearsay Relevance, Hearsay, Incomplete Relevance, Hearsay

DTX82A

Peterson Binder 23 beginning at BL005 ­ 023000 Bayer v. DRL Reddy's Fifth Notice of 30(b)(6) Deposition of Bayer (D83) "Synthesis and In Vitro Activity of BAY 12-8039, a New 8Methoxyquinolone" (D84) (and certified translation, DRLMOX 035870 ­ 035875) Information Disclosure Statement (US Serial No. 580,906) (D85) (and certified translation, BL005-051703 ­ 51707) 5/31/05

DTX83

DTX84

BL005-019300

Relevance

DTX85

DRLMOX 035867 ­ 035875

2/26/91

DTX86

BL005-035000, BL005036206 ­ 036207, BL005036260 ­ 036261, BL005037204 ­ 037205, BL005037817 ­ 037818 BL005-036260 ­ 036261

Literature Data Cards (D86)

8/25/87

DTX87

Literature Data Cards (D87)

12/9/83

Relevance, Incomplete, Hearsay as to Search Report and copies of references Relevance, Multiple Documents, Hearsay, Incomplete, Authenticity Relevance, Hearsay

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Trial Ex. No. DTX88

Bates No. BL005 ­ 051495 ­ 6; BL005 ­ 051526 ­ 7; BL005 ­ 051531; BL005 ­ 051536 ­ 8; BL005 ­ 051544 ­ 6; BL005 ­ 051550; BL005 ­ 051565; BL005 ­ 051578 ­ 80; BL005 ­ 051679; BL005 ­ 051682 ­ 7; BL005 ­ 051700 ­ 1; BL005 ­ 051703 ­ 7; BL005 ­ 051749 ­ 67; BL005 ­ 051778 ­ 85; BL005 ­ 051787 ­ 94; BL005 ­ 051798 ­ 9; BL005 ­ 051832 ­ 6; BL005 ­ 051842 ­ 3; BL005-051877 ­ 8; BL005 ­ 052206 ­ 17. BL005-036206 ­ 036207

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Petersen binder 26108 I (D88) (and certified translation, BL005-051703 ­ 51707) 10/4/90

Objections1 Relevance, Hearsay, Multiple Documents, Authenticity

DTX89

Literature Data cards (D89)

8/25/87

Relevance, Hearsay

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Trial Ex. No. DTX90

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Bayer's Patent Files re: LeA 25 727 (D90) 1/18/89

Objections1 Relevance, Hearsay

DTX91 DTX92 DTX93

BL012 - 005772 ­ 3; BL012 ­ 005777 ­ 9; BL012 ­ 005785 ­ 6; BL012 ­ 005788; BL012 ­ 005800; BL012 ­ 005823 ­ 4; BL012 ­ 005842 ­ 8; BL012 ­ 005862 ­ 76; BL012 ­ 005878 ­ 82; BL012 ­ 005901 ­ 3; BL012 ­ 005915 ­ 20; BL012 ­ 005922 ­ 4; BL012 ­ 005926; BL012 ­ 005931; BL012 ­ 005959 ­ 71; BL012 ­ 005975 ­ 8; BL012 ­ 006076 ­ 9; BL012 ­ 006108 ­ 12. BL001-011005 ­ 011111 BL001-013005 ­ 013058 BL001-014000 ­ 0014376; BL001-014378 ­ 014393.

DTX94

US Patent No. 5,059,597 (D91) US Patent No. 5,416,096 (D92) Bayer's Patent Files re: abandoned 08/026,906 prosecution history, as produced by Bayer (D93) Reddy's Sixth Notice of 30(b)(6) Deposition of Bayer (D94)

10/22/91 5/16/95 3/5/99

Relevance Relevance Relevance, Hearsay

6/3/05

Relevance, Hearsay

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Trial Ex. No. DTX95

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Pages from Bayer's Patent Files re: LeA 26108 (D95) 6/30/89

Objections1 Relevance, Hearsay, Incomplete

DTX96 DTX97

BL001-001000 ­ 001287; 001303 ­ 001304;001308;001311 ­ 001312;001314;001319;00 1342 ­ 001344;001365 ­ 001366;001369;001374 ­ 001374;001379 ­ 001385;001414 ­ 001415;001435 ­ 001436;001439;001448;00 1453 ­ 001455;001464 ­ 001465;001467. DRLMOX041012 ­ 041632 DRLMOX041711 ­ 041781 BL001-011000 ­ 011132; 0011155; 0011159 ­ 0011172; 011176 ­ 011183; 011187 ­ 011189; 011200 ­ 011207; 011213 ­ 011214; 011218

DTX98

US Patent No. 4,990,517 File History (D96) Certified copy of MPEP Chapter 600, 5th Edition and 8th Revision Dated May 1988 (D97) US Patent 5,059,597 from Bayer's records (D98)

2/17/95 5/88

Relevance, Hearsay Relevance, Hearsay

10/22/91

Relevance, Hearsay

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Trial Ex. No. DTX99

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date File History of Application No. 07/737,631 from Bayer's records (D99) 09/30/93

Objections1 Relevance, Hearsay

DTX100

BL001-012000 ­ 012002; 012006 ­ 012009; 012011 ­ 012012; 012020 ­ 012024; 012041 ­ 012045; 012050 ­ 012058; 012061 ­ 012069; 012088 ­ 012096; 012102 ­ 012111; 012119 ­ 012128; 012136 ­ 012140; 012142 ­ 012149; 012157 ­ 012162. BL001 - 026000 ­ 026001; 026211 ­ 026214; 026251 ­ 026353; 026541 ­ 026542; 026597 ­ 026641; 026651 ­ 026732; 026751 - 026752

Portion of File History - LeA26 108 EP from Bayer's records (D100)

6/30/89

Relevance, Hearsay, Incomplete

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Trial Ex. No. DTX101

Bates No. BL001-0015000­ 0015058; 015071 ­ 015072; 015075 ­ 015076; 015081; 015087 ­ 015096; 015101 ­ 015102; 015110 ­ 015120; 015122 ­ 015126; 015130 ­ 015137; 015140; 015142 ­ 015151; 015158 ­ 015159; 015176 ­ 015180; 015206 ­ 015212.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date File history of Le A 26 108-USA 4 from Bayer's records 4/10/90

Objections1 Relevance, Hearsay

DTX102 DTX103 DTX104 DTX105 DTX106 DTX107 DTX108 DTX109 DTX110 DTX111 DTX112

INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK Expert Report of Dr. Edmond J. LaVoie, Ph.D. (D112)

7/13/05

Relevance, Hearsay, Incomplete

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Trial Ex. No. DTX113

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Volume I: Attachments A-K to the Expert Report of Dr. Edmond J. LaVoie, Ph.D. (D113) Volume II: Attachments L-X to the Expert Report of Dr. Edmond J. LaVoie, Ph.D. (D113A) 7/13/05

Objections1 Multiple Documents, Hearsay, Relevance Multiple Documents, Hearsay, Relevance, Incomplete at to Exhibit Q Hearsay, Relevance Multiple Documents, Hearsay, Relevance

DTX113A

7/13/05

DTX114 DTX115

DTX116 DTX117 DTX118 DTX119 DTX120 DTX121 DTX122 DTX123

Expert Report of Dr. Rory P. Remmel, Ph.D. (D114) DRLMOX 041901 ­ 41910 Nakamura, et al., "In vitro Antibacterial Activity of AT-3295, a New Pyridonecarboxylic Acid Derivative," Recent Advances in Chemotherapy Antimicrobial Section 2, Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 1985 (D115) INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK US Patent No. 4,670,444 (D120) File History, US Patent No. 4,990,517 (D121) File History, US Patent No. 5,607,942 (D122) INTENTIONALLY LEFT BLANK

9/12/05 1985

6/2/87 2/5/91 3/4/97

Relevance Relevance, Hearsay Relevance, Hearsay

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Trial Ex. No. DTX124

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Chemical structure drawing, 5 structures (D124)

Objections1 Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Relevance, Incomplete Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation

DTX125

Chemical structure drawing, 4 structures (D125)

DTX125A

Chemical Structure drawing, 4 structures (Exhibit D125 with the valences satisfied, of nitrogen) (D125A) File History Section: Preliminary Amendment App. Ser. No. 07/737,631 (D126) Chemical structure drawing, 2 structures (D127) 3/20/95

DTX126

DTX127

DTX128 DTX129 DTX130 DTX131 DTX131A DTX132

INTENTIONALLY LEFT BLANK Supplemental Expert Report of Dr. Edmond J. LaVoie, PH.D. (D129) INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK INTENTIONALLY LEFT BLANK Page 16 of 39

12/1/05

Relevance, Hearsay

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Trial Ex. No. DTX133

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date

Objections1 Relevance, Hearsay

DTX134

DTX135

DTX136

DTX137 DTX138 DTX139

DTX140

Taylor, et al., "New Synthetic Studies on Deazafolates," Chemistry and Biology of Pteridines 1989 (D133) BL020-000147 ­ 198 Petersen, "Quinolone Antibiotics: The Development of Moxifloxacin" (D134) BL020-000223 ­ 278 Petersen, "Quinolone Antibiotics: The Development of Moxifloxacin" (D135) DRLMOX 041546 ­ 41552 (US Serial No. 375,434) Information 11/16/90 Disclosure Statement (with attachments) (and certified translation) (D136) WO 89/05643 (D137) 6/29/89 DE 36 32 222 A1 (and certified 4/7/88 translation) (D138) BL005-020000; Petersen's notebook #20 (and BL005-020003 ­ 81; certified translation, BL005-020141 BL005-020094 ­ 162; ­ 20142) (D139) BL005-020173 ­ 7; BL005-020183 ­ 288; BL005-020291 ­ 3; BL005-020295 ­ 348; BL005-020350 ­ 435; BL005-020437 ­ 446. DRLMOX 042552 - 42734 US Patent No. 5,071,999 File 12/10/91 History, Part 1 of 2 (Certified Copy) (D140)

Relevance, Hearsay, Relevance, Hearsay

Relevance, Hearsay as to Search Report and copies of references Relevance, Hearsay Relevance Relevance

Relevance, Hearsay

Page 17 of 39
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Page 18 of 40

Trial Ex. No. DTX140A

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date US Patent No. 5,071,999 File History, Part 2 of 2 (Certified Copy) (and certified translation, partial) (D140A) Petersen's notebook #22 (D141) 12/10/90

Objections1 Relevance, Hearsay

DRLMOX 042735 - 42923 (and 2-page trans.)

DTX141

BL005-022000 ­ 22055; BL005-022060; BL005-022066 ­ 109; BL005-022133 ­ 142; BL005-022162 ­ 5; BL005-022168 ­ 202; BL005-022211 ­ 33; BL005-022240 ­ 86; BL005-022288 ­ 93; BL005-022295 ­ 7; BL005-022311

Relevance, Hearsay

DTX142

Diagram (D142)

DTX143

Diagram (D143)

DTX144

Diagram (D144)

Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation

Page 18 of 39
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Page 19 of 40

Trial Ex. No. DTX145

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Diagram (D145)

Objections1 Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation

DTX146

Diagram (D146)

DTX147

Diagram (D147)

DTX148

Diagram (D148)

DTX149

Page w/6 structures numbered 0 ­ 6 (D149)

DTX150

Model (D150)

Page 19 of 39
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Page 20 of 40

Trial Ex. No. DTX 150A

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date HGS Model (D150A)

Objections1 Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation

DTX151

Model (D151)

DTX 151A

HGS Model (D151A)

DTX152

Model (D152)

DTX152A

HGS Model (D142A)

DTX153

Model (D153)

Page 20 of 39
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Filed 03/03/2006

Page 21 of 40

Trial Ex. No. DTX153A

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date HGS Model (D153A)

Objections1 Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation

DTX154

Model (D154)

DTX154A

HGS Model (D154A)

DTX155

Model (D155)

DTX155A

HGS Model (D155A)

DTX156

Model (D156)

Page 21 of 39
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Page 22 of 40

Trial Ex. No. DTX156A

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date HGS Model (D156A)

Objections1 Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Relevance, Hearsay Relevance Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation

DTX157

Chemical diagram (D157)

DTX158 DTX159

INTENTIONALLY LEFT BLANK Chemical diagram (D159)

DTX160 DTX161 DTX162

European Patent Application No. 0 215 650 A2 (D160) DE 36 01 567 A1 (D161) (and certified translation) Chemical Structure Diagram (D162)

9/12/86 1/21/86

DTX163

Chemical Structure Diagram (D163)

Page 22 of 39
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Filed 03/03/2006

Page 23 of 40

Trial Ex. No. DTX164

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Chemical Structure Diagrams (D164)

Objections1 Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Relevance, Hearsay Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Relevance, Hearsay Relevance, Hearsay, Incomplete

DTX165 DTX166

US Patent No. 4,665,079 (D165) Chemical Structure Diagrams (D166)

5/12/87

DTX167

Chemical Structure Diagrams (D167)

DTX168

Chemical Structure Diagram (D168)

DTX169

Chemical Structure Diagram (D169)

DTX170 DTX171

Edmond Joseph LaVoie Curriculum Vitae (P30) Expert Report of Dr. Edmond J. LaVoie, Ph.D. (P31)

7/13/05

Page 23 of 39
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Page 24 of 40

Trial Ex. No. DTX172 DTX173 DTX174 DTX175

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Reply Expert Report of Dr. Edmond J. LaVoie, Ph.D. (P35) US Patent No. 4,341,784 (P36) European Patent Application 0 106 489 A2 (P37) Patent Abstracts of Japan Application No. 58009874, Publication No. 59137481 A (P38) US Patent No. 4,684,648 (P39) 9/12/05 7/27/82 4/25/84 1/26/83

Objections1 Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay

DRLMOX030245-030254 DRLMOX027092-027216 DRLMOX030743-030744

DTX176 DTX177 DTX178

DTX179 DTX180

DRLMOX 027247 ­ 027257 DRLMOX 030825 ­ 30835 US Patent No. 4,684,648 (P39R) Matsumoto, et al., "AT-3295. A New Pyridonecarboxylic Acid Derivative with Potent AntiBacterial Activity: Synthesis and Structure-Activity Relationships, 14th International Congress of Chemotherapy Abstracts No. P-3541 (P48) Certified copy of US Patent No. 5,607,942 (P51) Chemical structure diagrams (P52)

8/4/87 8/4/87 6/23/85 ­ 6/28/85

Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay, Multiple Documents

3/4/97 Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Relevance, Hearsay Relevance, Hearsay

DTX181 DTX182

DRLMOX 041523 ­ 30. DRLMOX 041664 ­ 041692

Pages from US Serial No. 07/375,434 (P59) Certified "original MPEP Chapter 800, 5th and 8th Revision" (P61) Page 24 of 39

4/14/90 5/88

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Page 25 of 40

Trial Ex. No. DTX183

Bates No. DRLMOX 041546 ­ 041547

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date US Patent No. 4,990,517, Serial No. 07/375,434 File History Section: Information Disclosure Statement and attached form 1449 (P62) 37 CFR 1.99: Rules of Practice in Patent Cases/National Processing Provisions Information Disclosure Statement (Printout from Westlaw) (P63) Certified MPEP Chapter 600, 5th Edition and 8th Revision Dated May 1988 (P64) US Patent No. 4,990,517, Serial No. 07/375,434 File history section: Patent Office cover page (P65) US Patent No. 4,990,517, Serial No. 07/375,434 File history section: Request for Certificate Under 37 CFR 1.322 (P67) Certified: "The Original MEP Chapter 2000, 5th Edition and 3rd Revision Dated may 1986" (P70) Expert Report of Dr. Rory P. Remmel, Ph.D. (P71) Data Sheet (P77) 11/16/90

Objections1 Relevance, Incomplete

DTX184

Relevance, Hearsay

DTX185

5/88

Relevance, Hearsay

DTX186

DRLMOX 041013

7/16/89

Relevance, Hearsay

DTX187

DRLMOX 041560 ­ 041564

2/16/95

Relevance

DTX188

DRLMOX 041633 ­ 041663

5/86

Relevance, Hearsay

DTX189

9/12/05

DTX190

Relevance, Hearsay, Incomplete Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation

Page 25 of 39
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Filed 03/03/2006

Page 26 of 40

Trial Ex. No. DTX191 DTX192 DTX193 DTX194

Bates No. BL012-006330 ­ BL012006338

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date File History Section re: App. Serial No.06/815440 (P100) Declaration of John L. Sang (with attachments) Stipulation (to the admissibility of the Declaration of John L. Sang) Reddy's Notice of 30(b)(6) Deposition to Bayer. - Dated April 20, 2005 Reddy's Fourth Notice of 30(b)(6) Deposition of Bayer. - Dated May 27, 2005 Bayer's Responses to Dr. Reddy's First Set of Requests for Admission (Nos. 1-24) - Dated May 31, 2005 Bayer's Objections and Responses to Dr. Reddy's Second Set of Requests for Admission (Nos. 2550) - Dated June 6, 2005 Bayer's Objections and Responses to Dr. Reddy's Requests for Admission (Nos. 51-53). ­ Dated June 9, 2005 Bayer's Amended Response to Request No. 1 of Dr. Reddy's First Set of Request for Admission (Nos. 1-24) - Dated June 10, 2005 Bayer's Amended Response to Request No. 14 of Dr. Reddy's First Set of Requests for Admission (Nos. 1-24) - Dated December 16, 2005 Page 26 of 39 4/16/86 2/10/05

Objections1 Relevance, Hearsay Relevance Relevance

4/20/05

Relevance, Hearsay

DTX195

5/27/05

Relevance, Hearsay

DTX196

5/31/05

Relevance

DTX197

6/6/05

Relevance

DTX198

6/9/05

Relevance

DTX199

6/10/05

Relevance

DTX200

12/16/05

Relevance

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Page 27 of 40

Trial Ex. No. DTX201

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Discovery Agreement concerning the Sankyo and Dainippon references. - Dated February 1, 2005 E-Mail from Adam Perlman to Louis Weinstein - Dated February 16, 2005 Bayer's Objections and Responses to Dr. Reddy's First Set of Interrogatories. - Dated December 15, 2004 Bayer's Supplemental Objections and Responses to Dr. Reddy's First Set of Interrogatories. - Dated January 18, 2005 Bayer's Objections and Responses to Dr. Reddy's Second Set of Interrogatories (Nos. 8-10) - Dated January 21, 2005 Bayer's Amended Supplemental Objections and Responses to Interrogatories Nos. 2 and 3 of Dr. Reddy's First Set of Interrogatories. - Dated January 31, 2005 Bayer's Objections and Responses to Dr. Reddy's Third Set of Interrogatories (Nos. 11-13). - Dated May 18, 2005 Bayer's Supplemental Objections and Responses to Interrogatory No. 11 of Dr. Reddy's Third Set of Interrogatories (Nos. 11-13) - Dated May 23, 2005 Page 27 of 39 2/1/05

Objections1 Relevance

DTX202

2/16/05

Relevance

DTX203

12/15/04

Relevance

DTX204

1/18/05

Relevance

DTX205

1/21/05

Relevance

DTX206

1/31/05

Relevance

DTX207

5/18/05

Relevance

DTX208

5/23/05

Relevance

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Document 108-8

Filed 03/03/2006

Page 28 of 40

Trial Ex. No. DTX209

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Bayer's Objections and Responses to Dr. Reddy's Fourth Set of Interrogatories (Nos. 14-31) - Dated June 6, 2005 Bayer's Objections and Responses to Reddy's Fifth Set of Interrogatories (Nos. 32-43) Dated June 6, 2005 Bayer's Objections and Responses to Reddy's Sixth Set of Interrogatories (No. 44) - Dated June 9, 2005 Bayer's Supplemental Responses to Dr. Reddy's Interrogatories Nos. 14, 15, 16, 21, 22, 24, 26, 28, 29, 32 and 33.- Dated August 3, 2005 Birkofer, et al., Justus Liebigs Ann. der Chemie, Vol. 677 (1964) page 154 ­ 157 (and certified translation) Bayer Privilege Log (By Date) Bayer Privilege Log (By Bates Number) Bayer Supplemental Privilege Log (By Date) Bayer Supplemental Privilege Log (By Bates Number) Documents from 5,071,999 File History (and certified translation) Birkofer, et al., Justus Liebigs Ann. der Chemie, 677, 154-157 (1964) Page 28 of 39 6/6/05

Objections1 Relevance

DTX210

6/6/05

Relevance

DTX211

6/9/05

Relevance

DTX212

8/3/05

Relevance

DTX213

DRLMOX 035838 ­ 035839

12/23/63

Relevance, Hearsay

DTX214 DTX215 DTX216 DTX217 DTX218 DRLMOX042815 ­ 19

Relevance Relevance Relevance Relevance Relevance, Hearsay as to copy of reference Relevance, Hearsay

DTX218 A
588023w

DRLMOX042817-042819

12/23/63

Case 1:04-cv-00179-SLR

Document 108-8

Filed 03/03/2006

Page 29 of 40

Trial Ex. No. DTX218 B DTX219

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Birkofer, et al., Justus Liebigs Ann. der Chemie, 677, 154-157 (1964) Ortho Diagnostics Systems Inc. v. Miles Inc., S.D.N.Y. No. 90 CIV. 5043, "Defendant Miles Inc.'s Motion to Alter or Amend Judgment to Include Finding of Inequitable Conduct" and memorandum in support Ortho Diagnostics Systems Inc. v. Miles Inc., S.D.N.Y. No. 90 CIV. 5043, "Ortho's Memorandum in Opposition to Miles' Motion for Amendment of the Judgment to Include a Finding of Inequitable Conduct Ortho Diagnostics Systems Inc. v. Miles Inc., S.D.N.Y. No. 90 CIV. 5043, Opinion and Order Ortho Diagnostics Systems Inc. v. Miles Inc., S.D.N.Y. No. 90 CIV. 5043, "Miles Reply Memorandum in Support of its Motion to Alter or Amend Judgment to Include Finding of Inequitable Conduct Pages from Sprung Horn's Patent Files re: abandoned 08/026,906 prosecution history EP-241-206A Abstract SANY 23.06.87 Abstract Page 29 of 39 12/23/63 8/10/94

Objections1 Relevance, Hearsay Relevance, Hearsay

B 0001 ­ 177

DTX220

B 0178 ­ 209

9/12/94

Relevance, Hearsay

DTX221

DRLMOX 043964 - 43979

10/21/94

Relevance, Hearsay

DTX222

DRLMOX 043946 - 43963

9/28/94

Relevance, Hearsay

DTX223

DTX224 DTX225

SH_000001-004967 ­ 8; SH_000001-005103 ­ 27; SH_000001-005129 ­ 63; SH_000001-005169 ­ 223. BL005-038418 ­ 38420 BL005-038017 ­ 38018

Relevance, Hearsay, Multiple Documents 3/31/86 6/23/87 Relevance, Hearsay Relevance, Hearsay

588023w

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Document 108-8

Filed 03/03/2006

Page 30 of 40

Trial Ex. No. DTX226

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date 50 FR 5172, Feb. 6, 1985 Abstracts from the 14th International Congress of Chemotherapy June 2328, 1995, including sign-out cards Protocol of the 15th Project Meeting on Quinolone on Apr. 4, 1989 (and Certified Translation) Minutes of 8th Quinolone Project Meeting on 6/28/1988 (certified translation) Original of DTX5 (Bayer to bring to trial) Certified copy of Japanese 59204194 (and Certified Translation) Certified EP 0 241 206 A2 (with corrected cover page) Certified File History, US Patent No. 4990517 (App. No. 07/375,434) (Part 1 of 5) Certified File History, US Patent No. 4990517 (App. No. 07/375,434) (Part 2 of 5) Certified File History, US Patent No. 4990517 (App. No. 07/375,434) (Part 3 of 5) Certified File History, US Patent No. 4990517 (App. No. 07/375,434) (Part 4 of 5) Page 30 of 39 2/6/85

Objections1 Relevance, Hearsay, Incomplete Relevance, Hearsay

DTX227

BC005-000001 ­ 487

6/23/95

DTX228

BL005-001065 ­ 001094

4/4/89

Relevance

DTX229

BL005-001174 ­ 001188

6/29/88

Relevance

DTX230 DTX231 DTX232 DTX233 DRLMOX009160 ­ 9163 DRLMOX044007 ­ 44195 DRLMOX006791 ­ 007039 DRLMOX007040 ­ 007324 DRLMOX007326 ­ 007624 DRLMOX007625 ­ 007955

11/19/84 10/14/87

Relevance, Hearsay as to attachments Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay

DTX234

Relevance, Hearsay

DTX235

Relevance, Hearsay

DTX236

Relevance, Hearsay

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Filed 03/03/2006

Page 31 of 40

Trial Ex. No. DTX237

Bates No. DRLMOX007956 ­ 8178

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date

Objections1 Relevance, Hearsay

DTX238 DTX239 DTX240 DTX241 DTX242 DTX243 DTX244 DTX245 DTX246

DTX247 DTX248 DTX249 DTX250

Certified File History, US Patent No. 4990517 (App. No. 07/375,434) (Part 5 of 5) DRLMOX 042955 ­ 43325 Certified File History, US Patent No. 5,607,942 (Volume 1 of 2) DRLMOX 043326 ­ 43702 Certified File History, US Patent No. 5,607,942 (Volume 2 of 2) Certified File History, US Patent No. 5,059,597 DRLMOX042019 ­ Certified MPEP Chapter 700, 5th 042115 Edition, Revision 6 DRLMOX041911 ­ Certified MPEP Chapter 800, 041963 Revision 1 DRLMOX041964 ­ Certified MPEP Chapter, Chapter 042018 800, Revision 2 DLRMOX030842 ­ Certified Patent, European Patent 030845 No. 0,326,916 DRLMOX030836 ­ 30838 Certified Patent, Japanese Patent Abstract for JP 59-219293 DRLMOX030839 ­ Certified Patent, Japanese Patent 030841 Abstract Publication Number 59137481 DRLMOX011923 ­ Certified Patent, Japanese Patent JP 011927 60-23381 DRLMOX011928 ­ Certified Patent, Japanese Patent JP 011932 60-23382 DRLMOX009164 ­ Certified Patent, Japanese Patent No. 009169 59-137481 DRLMOX043980 ­ 44006 Certified Patent, DE 36 01 567 A1 (and certified translation) Page 31 of 39

Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay 1/25/89 10/12/84 7/8/84 Relevance Relevance, Hearsay Relevance, Hearsay

2/5/85 2/5/85 8/7/94 7/23/87

Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance

588023w

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Page 32 of 40

Trial Ex. No. DTX251 DTX252 DTX253 DTX254 DTX255 DTX256 DTX257 DTX258 DTX259 DTX260 DTX261

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Certified Patent, US Patent No. 4,920,120 Certified Patent, US Patent No. 4,980,470 Certified Patent, US Patent No. 4,997,943 Certified Patent, US Patent No. 4,666,920 Certified Patent, US Patent No. 5,071,999 Certified Patent, EP 0 106 489 A2 Certified Patent, EP 0 195 316 Certified Patent, US 4,341,784 Certified Patent, US 4,649,144 Certified Patent, US 4,684,648 Japanese Unexamined Patent Application Publication S60-126284 (and Certified Translation) Patent number JP60-126284 and translation 1/31/05 Letter from A. Perlman to L. Weinstein 2/4/05 Letter from A. Perlman to L. Weinstein 4/13/05 E-mail from A. Perlman to B. Radin 4/24/90 12/25/90 3/5/91 5/19/87 12/10/91 4/25/84 9/24/86 7/27/82 3/10/87 8/4/87 7/5/85

Objections1 Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay

DLRMOX009079 ­ 009105 DRLMOX009137 ­ 009151 DRLMOX009106 ­ 009136 DRLMOX041693 ­ 41703 DRLMOX042531 ­ 042551 DRLMOX 043769 ­ 43894 DRLMOX 043703 ­ 43746 DRLMOX 043907 ­ 43917 DRLMOX 043918 ­ 43945 DRLMOX 043895 ­ 43906 DRLMOX026805 ­ 026825 DRLMOX 009152-9159

DTX261A DTX262 DTX263 DTX264

Relevance, Hearsay 1/31/05 2/4/05 4/13/05 Relevance Relevance Relevance

Page 32 of 39
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Page 33 of 40

Trial Ex. No. DTX265

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date 5/31/05 Letter from D. Grossman to L. Weinstein re: enclosing Bayer's responses to Reddy's first set of requests for admissions, and addressing errors in privilege log entries 6/8/05 Facsimile from D. Grossman to L. Weinstein re: revisions to Bayer's privilege log 6/10/05 Facsimile from D. Grossman to L. Weinstein re: revision to privilege log 6/10/05 Facsimile from D. Grossman to L. Weinstein re: revisions to privilege log (with attachments) 12/16/05 Letter from D. Grossman to L. Weinstein re: revision to privilege log entries Bayer v. Dr. Reddy Complaint Bayer v. Dr. Reddy Bayer's Answer to Counterclaims Hooper, et al., "Genetic and Biochemical Characterization of Norfloxacin Resistance in Escherichia coli," 29(4), 1986, p 639-644 Office Action re: US Serial No. 07/375,434 5/31/05

Objections1 Relevance, Incomplete

DTX266

6/8/05

Relevance

DTX267

6/10/05

Relevance, Incomplete Relevance

DTX268

6/10/05

DTX269

12/16/05

Relevance, Incomplete Relevance, Incomplete Relevance, Hearsay Relevance, Hearsay

DTX270 DTX271 DTX272

3/24/04 6/10/04 1986

DTX273

DRLMOX 041523 -30

04/04/90

Relevance, Hearsay

Page 33 of 39
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Document 108-8

Filed 03/03/2006

Page 34 of 40

Trial Ex. No. DTX274

Bates No. DRLMOX 041534 -7

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date File History Section re: US Serial No. 375,434 - Amendment Under Rule 111 Office Action Re: US Serial No. 07/375,434 - Examiner Interview Summary Record Office Action re: US Serial No. 07/375,434 Office Action re: US Serial No. 07/375,434 File History Section re: US Serial No. 07/375,434: Part B Issue Fee Transmit Office Action re: Appl. No. 89111950.5 ­ Mitteilung (and translation BL005-051703 ­ 051707) File History Section re: US Serial No. 07/375,434 ­ Contents 37 CFR § 1.56 -Code of Federal Regulations Title 37, Subchapter A, Part 1, Subpart B 37 CFR § 1.97 -Code of Federal Regulations Title 37, Subchapter A, Part 1, Subpart B 37 CFR § 1.98 -Code of Federal Regulations Title 37, Subchapter A, Part 1, Subpart B 37 CFR § 1.99 -Code of Federal Regulations Title 37, Subchapter A, Part 1, Subpart B Page 34 of 39 07/19/90

Objections1 Relevance, Incomplete Relevance, Hearsay

DTX275

DRLMOX 041538

08/27/90

DTX276 DTX277 DTX278

DRLMOX 041539 ­ 41 DRLMOX 041542 DRLMOX 041543-44

08/27/90 08/27/90 10/31/90

Relevance, Hearsay Relevance, Hearsay Relevance

DTX279

DRLMOX 041548 ­ 041552

07/11/90

Relevance, Hearsay

DTX280 DTX281

DRLMOX 041013

07/19/89

Relevance, Hearsay Relevance, Hearsay

DTX282

Relevance, Hearsay

DTX283

Relevance, Hearsay

DTX284

Relevance, Hearsay

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Document 108-8

Filed 03/03/2006

Page 35 of 40

Trial Ex. No. DTX285

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date 37 CFR § 1.311 -Code of Federal Regulations Title 37, Subchapter A, Part 1, Subpart B 37 CFR § 1.312 -Code of Federal Regulations Title 37, Subchapter A, Part 1, Subpart B 37 CFR § 1.313 37 CFR § 1.314 Certified MPEP Chapter 600, 5th Ed. and 8th Revision Certified MPEP Chapters 100 and 1300, 5th Ed. Patent Application (US Serial No. 07/580906) Preliminary Amendment (US Serial No. 07/580,906) File History Section re: US Serial No. 07/580,906: Information Disclosure Statement By Applicant, Cover Page & Attachment: Liebig's Ann. Der Chemie, Vol. 677 (1964) page 155 File History Section re: US Serial No. 07/580,906 -Information Disclosure Statement CV of Dr. Edmond J. LaVoie EP 0 195 316 A1 Page 35 of 39

Objections1 Relevance, Hearsay

DTX286

Relevance, Hearsay

DTX287 DTX288 DTX289 DTX290 DTX291

DRLMOX 041711 041781 DRLMOX 042166 042196 DRLMOX 035593 035788 DRLMOX 035789 035792 DRLMOX 035837 035841

05/88 08/83

Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Multiple Documents Relevance, Hearsay as to attachment Relevance, Hearsay as to copy of reference

DTX292

09/10/90

DTX293

09/10/90

DTX294

DRLMOX 035867 035875

02/21/91

DTX295 DTX296

DRLMOX 029086 ­ 029128

03/06/86

Relevance, Hearsay as to Search Report and copy of reference Relevance, Hearsay Relevance, Hearsay

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Page 36 of 40

Trial Ex. No. DTX297 DTX298 DTX299 DTX300 DTX301 DTX302

Bates No. DRLMOX 030245 ­ 030254 DRLMOX 030306 ­ 030327 DRLMOX 030743­ 4 DRLMOX 027247 ­ 57 DRLMOX 027092 ­ 027216 BL005-023386

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date US Patent 4,341,784 US Patent 4,649,144 Patent Abstracts of Japan ­ Pub. No. 59137481 A; Appl. No. 58009874 US Patent 4,684,648 EP 0 106 489 A2 14th International Congress of Chemotherapy ­ Kyoto, Japan (P35-41) US Patent 4,666,920 "Guideline for Submitting Supporting Documentation in Drug Applications For the Manufacture of Drug Substances" (Center for Drugs and Biologics, Food and Drug Administration, Dep. Of Health & Human Services) Ariens, "Stereochemistry, a Basis for Sophisticated Nonsense in Pharmacokinetics and Clinical Pharmacology," Eur J Clin Pharmacol (1984) 26:663-668 File History Section re: US Serial No. 07/580,906 ­ Patent Application re: Le A 26 108 07/27/82 03/10/87 08/07/84 08/04/87

Objections1 Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay, Multiple Documents Relevance Relevance, Hearsay

06/23/85

DTX303 DTX304

DRLMOX 040973 ­ 040982 DRLMOX 041782 ­ 041846

05/19/87 02/87

DTX305

DRLMOX 041704 ­ 041710

1984

Relevance, Hearsay

DTX306

DRLMOX 035595 ­ 035783

Relevance

Page 36 of 39
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Document 108-8

Filed 03/03/2006

Page 37 of 40

Trial Ex. No. DTX307

Bates No. DRLMOX 035789 ­ 91

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date File History Section re: US Serial No. 07/580,906 - Preliminary Amendment File History Section re: US Serial No. 07/580,906 File History Section re: US Serial No. 07/580,906 File History Section re: US Serial No. 07/580,906 Table of compound comparisons 09/10/90

Objections1 Relevance, Incomplete Relevance, Incomplete Relevance, Incomplete Relevance, Hearsay as to attachments Inadmissible Demonstrative, Relevance, Hearsay, Lack of Foundation Relevance Relevance, Hearsay Relevance, Hearsay

DTX308 DTX309 DTX310 DTX311

BL001-011200 ­ 202 BL001-11187-89 BL001-011203 ­ 207

DTX312 DTX313 DTX314

BL001-001376

Letter from Bayer to Sprung Horn Supplemental Remmel Expert Report Piddock, et al., Activities of New Fluoroquinolones against Fluoroquinolone-Resistant Pathogens of the Lower Respiratory Tract, Antimicrobial Agents and Chemotherapy, Nov. 1998, p. 295660

11/12/90 1/3/06 11/98

Page 37 of 39
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Filed 03/03/2006

Page 38 of 40

Trial Ex. No. DTX315

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Karlowsky, et al., Stable Antimicrobial Susceptibility Rates for Clinical Isolates of Pseudomonas aeruginosa from the 2001-2003 Tracking Resistance in the United States Today Surveillance Studies, Clinical Infectious Diseases 2005:40 (Suppl 2), pp. S89-98 Patent certification '517 patent Patent certification '942 patent Patent certification '752 patent ANDA Section III 2005

Objections1 Relevance, Hearsay

DTX316 DTX317 DTX318 DTX319

DRLMOX 001054 DRLMOX 001055 DRLMOX 001056 DRLMOX 001059-62

12/10/03 12/10/03 12/10/03 12/10/03

DTX320

BC002-000001 - 210.

Avelox NDA 50-764, Section 13: Declaration re: Patent Nos. 4,990,517 (and NDA cover page) Serial No. 580,906: Filing Receipt 14th International Congress of Chemotherapy Abstracts, June 23 ­ 28, 1985, Kyoto, Japan Federal Register Pages Manual of Patent Examining Procedure, identifying revisions Notebook pages, PEW 6862 Notebook page, PEW 6843 Notebook pages, PEW 6841 EP 0 132 845 A2 Page 38 of 39 9/28/90 6/23/85

DTX321 DTX322

BL001-011203 to BL001011207 BL005-023398 - 23453

Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay, Incomplete Relevance, Multiple Documents, Lack of Foundation Relevance, Hearsay as to attachments Relevance, Hearsay

DTX323 DTX324

DRLMOX 042924 - 42954 DRLMOX042136 - 42165

2/6/85

DTX325 DTX326 DTX327 DTX328
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BL008-011091 - 011106 BL008-011180 BL008-011183 - 11184

4/19/90 3/6/90 2/20/90

Relevance, Hearsay Relevance, Hearsay, Multiple Documents Relevance Relevance Relevance Relevance, Hearsay

Case 1:04-cv-00179-SLR

Document 108-8

Filed 03/03/2006

Page 39 of 40

Trial Ex. No. DTX329 DTX330 DTX331 DTX332 DTX333 DTX334

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date EP 0 230 274 A2 US Patent No. 4,777,175 US Patent No. 4,638,067 Martindale Hubbell listing for Leonard Horn, Kurt Briscoe Martindale listing for Leonard Horn, 1985 File History Section re: Serial No. 375,434: Request for Certificate Under 37 CFR 1.322 File History, EP 0 350 733 A2, Part 1 File History, EP 0 350 733 A2, Part 2 File History, US Patent No. 5,416,096 Patent Abstracts of Japan #58094097 European Patent EP0350733A2 (and Certified Translation, pages BL001026251, BL001-026348 ­ 026535) Summary pursuant to Rule 1006

Objections1 Relevance Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay Relevance, Incomplete Relevance, Hearsay Relevance, Hearsay Relevance, Hearsay

10/11/88 1/20/87

1985 2/16/95

DRLMOX 041560 ­ 2

DTX335 DTX336 DTX337 DTX338 DTX339

DRLMOX 044196 - 45529 DRLMOX 045530 - 46242 DRLMOX037154 ­ 38214 DLRMOX030741 - 30742 DRLMOX029624 - 29726

12/10/84 6/30/89

Relevance, Hearsay Relevance

DTX340

DTX341 DTX342

DE 3318145 A1 Bayer's Second Supplemental Response to Dr. Reddy's Interrogatory Page 39 of 39

1/11/06

Exhibit not provided. Bayer reserves all objections pending receipt of exhibit. Relevance Relevance

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Filed 03/03/2006

Page 40 of 40

Trial Ex. No. DTX343

Bates No.

CONTAINS CONFIDENTIAL INFORMATION BAYER V. DR. REDDY'S NO. 04-0179 Description Doc. Date Bayer's Third Supplemental Response to Dr. Reddy's Interrogatory No. 15 2/3/06

Objections1 Relevance

Page 40 of 39
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